The R-PLEX platform offers matched sets of antibodies and calibrators for a wide menu of biomarkers. The R-PLEX Human P-Selectin Antibody Set can be used with other MSD components (see "Recommended Components" tab below) to build assays that measure P-Selectin.

P-selectin is an adhesion receptor for leukocytes expressed by activated platelets and endothelial cells. To assess a possible role of P-selectin in platelet clearance, we adapted an in vivo biotinylation technique in mice. Wild-type and P-selectin–deficient mice were infused with N-hydroxysuccinimido biotin.

Produktnummer. : 561306. Märke. : Millipore. REACH Nr. : Denna produkt är en blandning.

P selectin

P-selectin, which is located together with beta-amyloid P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis. Artikel i interactions in the pancreas remain elusive, but selectins may play a role. By examining biomarkers of IRI including P-selectin by immunohistochemistry and/or quantitative PCR, liver histology and hepatic blood flow using established Pendu, R., Terraube, V., Christophe, O. D., Gahmberg, C. G., de Groot, P. G., Lenting, P. J., & Denis, C. V. (2006). P-selectin glycoprotein ligand 1 and beta Kinetics of platelet P-selectin mobilization: Concurrent surface expression and release induced by thrombin or PMA, and inhibition by the NO Donor SNAP av S Santén · 2009 · Citerat av 14 — Additionally, the role of p38 MAPK in mast cell-generated tumor necrosis factor-α (TNF-α) as well as neutrophil adhesion and P-selectin expression were Artikelnummer: 636393. Produktnamn: Ms X Hu P Selectin. REACH- registreringsnummer: Denna produkt är en blandning. Millipore Referens.

P-selectin that is expressed on the surface of the endothelium mediates abnormal rolling and static adhesion of sickle erythrocytes to the vessel surface in vitro. 13,14 Translocation of

P‑Selectin/CD62P in Mouse Liver. P-Selectin/CD62P was detected in perfusion fixed frozen sections of mouse liver using Goat Anti-Mouse/Rat P-Selectin/CD62P Antigen Affinity-purified Polyclonal Antibody (Catalog # AF737) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling.

P‑Selectin/CD62P in Mouse Liver. P-Selectin/CD62P was detected in perfusion fixed frozen sections of mouse liver using Goat Anti-Mouse/Rat P-Selectin/CD62P Antigen Affinity-purified Polyclonal Antibody (Catalog # AF737) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004).

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P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. P-selectin is partially responsible for the adhesion of certain leukocytes and platelets to the endothelium. Animal models have also shown the important role of P-selectin in the process of atherogenesis. P-Selectin, also known as CD62P, GMP-140, PADGEM, and LECAM-3, is a transmembrane adhesion protein that is upregulated on activated platelets and vascular endothelial cells. It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate, P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and platelets. E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines.
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Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils. In this video we discuss the three different types of selectins and their involvement in the immune system. 2007-07-15 · Ma, Y-Q., Plow, E.F. & Geng, J.-G.

CD62P Antigens.
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P. 1. Inscriptiones Phoenicias continens. T. 1: 1–3 (text & pl.). Paris 1881–85. Fol. S Papyri, Select, in the hieratic character from the collections of the British

Inflammatoriska cytokiner inducerar det omedelbara sättet eller sättet för expression av P-selectin på endotelcellytor och P-selectin binder svagt of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). S Papyri , Select , in the hieratic character from the collections of the British Museum . Regnaud , P. , De primigenia vocis Kshatriyari atque de regiis insignibus P. 1.

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P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions J Immunol . 1997 Oct 15;159(8):3929-39.

1,A and B). Search results for p-selectin at Sigma-Aldrich. Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. Identifying severe acute pancreatitis (SAP) as soon as possible is critical for achieving optimal outcomes and saving lives. In this study, a novel P-selectin-targeted, NIR fluorescent dye (Cy 5.5)-labeled dual-modal nanoprobe based on diethylenetriaminepentaacetic chelates (Gd-DTPA-Cy5.5-PsLmAb) was constructed for the bimodal imaging of SAP at the early stage. Gd-DTPA-Cy5.5-PsLmAb was 2003-12-01 Mechanisms for increasing synthesis of P-selectin are suggested by its presence on the apical surface of endothelial cells in human tissues with chronic or allergic inflammation.16-18 Indeed, TNF-α, IL-1β, or LPS increases expression of P-selectin mRNA and protein in murine endothelial cells in vitro and in vivo.10,19,20 Transient activation of the murine P-selectin gene requires the P-selectin is a 140-kDa transmembrane glycoprotein.

May 28, 2020 Although P-selectin expression is considered limited to platelets and endothelial cells (4), Yen et al. (12) surprisingly demonstrated the

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